Avascular Osteonecrosis of the Jaw as a Side Effect of Bisphosphonate Treatment
نویسندگان
چکیده
منابع مشابه
Avascular osteonecrosis of the jaw as a side effect of bisphosphonate treatment.
of ONJ [6–8], although such reports in the context of the large phase III trials of these agents are lacking. These reports included patients treated with sunitinib, an inhibitor of the tyrosine kinases of VEGF, PDGF, c-kit, FLT3 and RET, or bevacizumab, a monoclonal antibody, which solely inhibits VEGF. Taken together these reports underline the importance of VEGF in the development of ONJ. Th...
متن کاملOsteonecrosis of the jaw as a possible rare side effect of annual bisphosphonate administration for osteoporosis: A case report
INTRODUCTION Osteonecrosis of the jaw is a serious side effect in patients receiving nitrogen-containing bisphosphonates intravenously due to malignant diseases. Albeit far less frequently, osteonecrosis of the jaw has also been reported to occur due to the oral administration of nitrogen-containing bisphosphonates due to osteoporosis. Annual infusions of zoledronic acid have been recommended i...
متن کاملBisphosphonate-related osteonecrosis of the jaw
Bisphosphonates (BPs) have been used for the management of bone metabolic diseases. Currently their therapeutic use has increased, as also have their adverse effects, one of the most important being the bisphosphonate-related osteonecrosis of the jaw (BRONJ), a complication of diffi cult treatment and solution. Until now, the physiopathology of BRONJ remains unclear, and its treatment is uncert...
متن کاملBisphosphonate-induced osteonecrosis of the jaw.
Bisphosphonates are routinely used in the prevention and treatment of osteoporosis. Osteonecrosis of the jaw is known to be an important but rare complication of bisphosphonate usage. We present our experience with two patients of osteonecrosis of the jaw due to bisphosphonate usage.
متن کاملBisphosphonate-Related Osteonecrosis of the Jaw: Specificities
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe complication that has recently emerged in patients treated with intravenous bisphosphonates for malignant diseases. This complication usually presents after a minor local trauma during a dental treatment. Several etiopathogenic mechanisms of this pathological condition have been proposed, but no model can explain all morpholog...
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ژورنال
عنوان ژورنال: Onkologie
سال: 2010
ISSN: 1423-0240,0378-584X
DOI: 10.1159/000313684